Example Results
Example Results This is an example Navigenics Health Compass report.
All Health Conditions / Alzheimer's disease

Print this page

For scientists

Introduction

Introduction

The table below shows additional scientific details relating to the genetic markers we tested for this condition, including the frequency of each genotype in the closest HapMap population to the study population. For example, if the study was performed using samples from Great Britain, then we will report the genotype frequency in the CEU HapMap population.

In some cases, our test SNP is a proxy for the published SNP. In those cases, we have indicated the r2 value observed in the closest HapMap population from which the study was performed. r2 values of 1 indicate a perfect correlation of genotypes in the HapMap samples.

SNP chart

Detailed odds ratio table

Gene or
location Info Tip 		Risk marker Info Tip Your markers Info Tip Odds ratio Info Tip Reference population Info Tip Genotype frequencies Info Tip r2 with published SNP Info Tip Source Info Tip
APOE rs429358rs7412
E4/E4
E2/E2
TTTT
1.0 CEU
E4/E4 - 1.8%
E3/E4 - 21%
E2/E2 - 1.8%
E2/E4 - 1.8%
E3/E3 - 56%
E2/E3 - 18%
direct
direct
 Journal of Clinical Psychiatry, 2007
SNP chart

Genotype risk summary chart

Robustness of our Calculations

Robustness of our calculations

We tested the sensitivity of our estimated lifetime risk calculation to changes in the lifetime risk by calculating the Genetic Composite Index rank of every individual in the CEU population across varying values of lifetime risk estimates, ranging from 0 to 0.5. From this we calculated the average and standard deviation of the rank of each individual. We find that this condition is robust to changes in lifetime risk. This means that all individuals had a standard deviation lower than 5 percent. This implies that even though the estimates of your absolute risk may be quite different based on different average lifetime risk estimates, your estimates of risk compared to the population is highly robust. For a more detailed explanation of the Genetic Composite Index, please refer to our white paper on navigenics science.

Conditions that have fewer numbers of markers going into the composite score have a segmented distribution since fewer genotype combinations are possible. As new associations are discovered and added to our service, we will be able to provide a better measurement of how you compare with the rest of the population.

Additional References

Additional references

Heritability: The Genetic Basis of Common Diseases, 2ed. Ed: R. King, J. Rotter, A. Motulsky, 2002

Prevalence: Bachman. Neurology 42:115. 1992

Lifetime risk reference: Seshadri. Stroke. 37:345. 2006

Lifetime risk comment: lifetime risk (risk of getting disease from age 65 onward)