Breast Cancer

The following highlights relevant clinical data on breast cancer:

• 76% of individuals with breast cancer do not have a positive family history.¹
• Common genetic variants and environmental risk factors combine to affect breast cancer risk.²
• In the absence of a positive family history, mammograms generally begin at age 40 and detect disease after it is present.

Why Navigenics?

With Navigenics BC genotyping you have the potential to identify the 15% of people whose estimated average BC risk is 50% greater than the population’s risk.³

Clinical Relevance

	Breast Self Exam	Mammography	Navigenics Genotyping: Breast Cancer
Focus of test	Diagnosis	Diagnosis	Prevention
Timing	Any age	Usually after age 40	Any age*
Frequency	Monthly	Annually	Generally a one-time saliva collection

*Navigenics currently tests adults 18 years or older

The same test covers 26 other conditions, providing you with genetic risk information that informs clinical decision-making and preventative guidance.

Prevent chronic disease in the future by incorporating personal genetic risk today.

1. NCI CGEMS breast cancer data set: http://cgems.cancer.gov/data/, Hunter. Nat Genet 39:870. 2007
2. The Navigenics Health Compass addresses common genetic causes of breast cancer. It does not, however, specifically address more rare causes of familial breast cancer, such as BRCA mutations. So, individuals who have a strong family history of breast cancer, especially in relatives under age 50, may be at greater risk than the Navigenics Health Compass estimates and should consult a Genetic Counselor.
3. Based on Navigenics composite genetic risk calculations using a HapMap reference population. For more information on these calculations, including our mathematical models and curation practices, please see “The Science Behind the Navigenics Service,” a white paper found at http://www.navigenics.com/static/pdf/Navigenics-TheScience.pdf.