GCI index

In order to give your patient a picture of where they are relative to a reference population, your patient’s genetic make-up for the tested SNP is compared to the genotypes of the HapMap reference population.

This visual shows what percent of the reference population has a score lower, the same as, or higher than your patient. Individuals at the lower end of the distribution have low to moderate genetic load and individuals at the very high end of the distribution have a high genetic load (i.e. carry many risk markers.

Using computer models, we have shown that individuals with moderately increased genetic risk typically have a two-fold increase in odds of disease compared with individuals with less than moderate genetic risk. However, individuals at the extreme upper end of the distribution (those in the highest percentile of the distribution) have odds of four to greater than ten depending on the condition considered.